Session 14

Complex environmental mixtures - a challenge for understanding the mechanism of toxic action of PAHs

Programme of the Session

S14-01
Metabolic Activation of Petrogenic Polycyclic Aromatic Hydrocarbons (PPAH): Potential Biomarkers for Human Exposure to Oil Spills
Trevor Penning¹, Meng Huang¹, Clementina Mesaros¹, Ian Blair¹, Sharon Croisant², Cornelis Elferink²
¹Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, United States; ²Center for Environmental Toxicology, University of Texas Medical Branch, Galveston, United States
S14-02
Mechanisms of toxicity of particulate engine emissions from diesel and alternative fuels under realistic traffic conditions
Jan Topinka¹, Michal Vojtisek-Lom², Jiri Klema³, Miroslav Machala⁴, Helena Libalova¹
¹Department of Genetic Toxicology and Nanotoxicology, Institute of Experimental Medicine CAS, Prague, Czech Republic; ²Center of Vehicles for Sustainable Mobility, Czech Technical University in Prague, Prague, Czech Republic; ³Department of Cybernetics, Czech Technical University in Prague, Prague, Czech Republic; ⁴Department of Chemistry and Toxicology, Veterinary Research Institute, Brno, Czech Republic
S14-03
Interference of polycyclic aromatic hydrocarbons and their complex mixtures with steroid signaling
Jan Vondracek¹, Martina Hyzdalova^{1, 2}, Jakub Pivnicka^{1, 3}, Ondrej Zapletal^{1, 3}, Gerardo Vazquez-Gomez¹, Jason Matthews⁴, Jiri Neca², Miroslav Machala²
¹Institute of Biophysics of the CAS, Brno, Czech Republic; ²Veterinary Research Institute, Brno, Czech Republic; ³Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic; ⁴University of Oslo, Oslo, Norway
S14-04
The genome as a record for environmental exposure to polycyclic aromatic hydrocarbons
Volker M. Arlt¹, Jill E. Kucab¹, Madeleine Joel¹, Serena Nik-Zainal², Michael R. Stratton², David H. Phillips¹
¹Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom; ²Wellcome Trust Genome Campus, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
S14-05
The Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons in the Transgenic Rodent Muta™Mouse
Alexandra Long¹, Christine Lemieux¹, Volker Arlt², Iain Lambert³, Paul White¹
¹Health Canada, Ottawa, Canada; ²King's College London, London, United Kingdom

Session Abstract

Humans are rarely environmentally exposed to single toxic substances but more commonly to complex mixtures. In order to evaluate the health risks posed by these chemicals understanding their mode of action is critical for accurate risk assessment. It is only modes and mechanisms that can assign causation of adverse outcomes from chemical exposure. Given the great interest in the human health hazards/risks of complex mixtures of combustion-derived mutagenic carcinogens the workshop will focus on the mechanisms of (geno)toxicity of polycyclic aromatic hydrocarbons (PAHs). The session will provide a forum to present current approaches for human health risk assessment and management of complex PAH mixtures including those by international regulatory authorities. The workshop will provide an opportunity for critical evaluation of risk assessment methods and approaches; and moreover, the development of an agenda to develop and deploy novel methods for the assessment and management of hazards/risks posed by complex mixtures of combustions-derived mutagenic carcinogens (i.e. PAHs) such as those present in vehicular exhausts and urban air. The session will also focus on the underlying mechanisms of PAH carcinogenesis and host factors (e.g. metabolism, inflammation, endocrine disruption) that are involved in mediating adverse toxic and/or carcinogenic responses of PAHs in exposed individuals. The session brings together world-leading experts in genetic, molecular & environmental toxicology and cancer biology.