CEC 3

10:00 – 10:15	CE course opening and introduction
10:15 – 10:55	Drug-induced liver injury: role of obesity and nonalcoholic fatty liver disease  Bernard Fromenty INSERM, U991, Rennes-1 University, France
10:55 – 11:35	Mechanisms of drug-induced lactic versus non-lactic endogenous acidosis   Bruno Mégarbane  Lariboisière Hospital, Paris-Diderot University, France
11:35 – 12:00	Discussion
12:00 – 13:00	Lunch
13:00 – 13:40	Mechanisms of drug-induced hyperamonemia Florian Eyer Department of Toxicology, Klinikum rechts der Isar, Germany
13:40 – 14:20	Mechanisms of drug-induced methemoglobinemia   Sally Bradberry Director of Poison Center West Midlands Poisons Unit, City Hospital
14:20 – 15:00	Mechanisms of glycol-induced renal toxicity (including ethylene and di-ethylene glycol)   Ken McMartin  Louisiana State University Health Sciences Center - Shreveport Louisiana, USA
15:00 – 15:40	Contribution of solvents in pesticide toxicity     Michael Eddleston NPIS Edinburgh, Royal Infirmary, UK
15:40 – 16:00	Discussion and Closing of the CE course

Investigating the mechanisms of toxicity in humans is helpful to understand the patterns and variability of presentations and to improve patient management. This Continuing Education Course aims to present the new insights in mechanisms of toxicity resulting from metabolic pathways as well as their relevance to clinical toxicology. Several metabolic impairments will be considered like non-lactic endogenous acidosis, hyperamonemia, methemoglobinemia, acute renal failure and liver injury. Recently published experimental data on acetaminophen, glycol and pesticide poisoning with high relevance to clinical toxicology will be presented.

14:20 – 15:00